Anti-gamma-H2AX

Anti-gamma-H2AX
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
A300-081B 100 µg -

3 - 9 business days

-
 
Protein function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.... more
Product information "Anti-gamma-H2AX"
Protein function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. [The UniProt Consortium]
Keywords: Anti-H2AX, Anti-H2a/x, Anti-H2AFX, Anti-Histone H2AX, Anti-Histone H2A.X
Supplier: Bethyl Laboratories
Supplier-Nr: A300-081B

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Bovine, Dog, Rabbit, Guinea Pig, Swine, Rhesus Monkey, Gorilla, Crab-eating Macaque, Chinese Hamster, Thirteen-lined Ground Squirrel, Little Brown Bat)
Immunogen: synthetic peptide. The epitope recongized by A300-081B maps to a region surrounding phosphorylated serine 139 of human histone H2AX using the numbering given for Swiss-Prot entry P16104 (GeneID 3014).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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