Anti-FXR (Farnesoid X-activated Receptor, Bile Acid Receptor, BAR, HRR-1, Nuclear Receptor Subfamily

Anti-FXR (Farnesoid X-activated Receptor, Bile Acid Receptor, BAR, HRR-1, Nuclear Receptor Subfamily
Item number Size Datasheet Manual SDS Delivery time Quantity Price
F9300-02.100 100 µl - -

3 - 19 business days*

498.00€
 
The steroid receptor superfamily acts through direct association with DNA sequences known as... more
Product information "Anti-FXR (Farnesoid X-activated Receptor, Bile Acid Receptor, BAR, HRR-1, Nuclear Receptor Subfamily"
The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed ",orphan receptors", because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: F9300-02

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: A synthetic peptide made to the C-terminus of the human FXR protein.
Purity: Purified by immunoaffinity chromatography.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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