Anti-Fibulin 5

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-63037.60 60 µl -

7 - 16 business days*

198.00€
E-AB-63037.120 120 µl -

7 - 16 business days*

317.00€
E-AB-63037.200 200 µl -

7 - 16 business days*

525.00€
 
The protein encoded by this gene is a secreted, extracellular matrix protein containing an... more
Product information "Anti-Fibulin 5"
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). Protein function: Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108). [The UniProt Consortium]
Keywords: Anti-UP50, Anti-FBLN5, Anti-Dance, Anti-DANCE, Anti-FIBL-5, Anti-Fibulin-5, Anti-Urine p50 protein, Anti-Developmental arteries and neural crest EGF-like protein, Fibulin 5 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-63037

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Recombinant protein of human FBLN5

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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