Anti-Fibrillarin

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A303-891A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A303-891A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to... more

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Product information "Anti-Fibrillarin"

Protein function: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239). [The UniProt Consortium]

Keywords:	Anti-FBL, Anti-FIB1, EC=2.1.1.-, Anti-Histone-glutamine methyltransferase, Anti-34 kDa nucleolar scleroderma antigen, Anti-rRNA 2'-O-methyltransferase fibrillarin
Supplier:	Bethyl Laboratories
Supplier-Nr:	A303-891A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: bovine, dog, horse, rabbit, guinea pig_10141, pig, panda, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, green monkey, crab-eating macaque, african elephant, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A303-891A-T maps to a region between residue 271 and 321 of human Fibrillarin using the numbering given in entry NP_001427.2 (GeneID 2091).
Format:	Antigen Affinity Purified