Anti-FBXW7

Anti-FBXW7
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F53267-0.08ML 80 µl - -

3 - 10 business days

207.00€
NSJ-F53267-0.4ML 400 µl - -

3 - 10 business days

503.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Substrate recognition component of an SCF... more
Product information "Anti-FBXW7"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. [UniProt] Protein function: Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). [The UniProt Consortium]
Keywords: Anti-hAgo, Anti-hCdc4, Anti-SEL-10, Anti-F-box protein FBX30, Anti-Archipelago homolog, Anti-F-box/WD repeat-containing protein 7, Anti-F-box and WD-40 domain-containing protein 7, FBXW7 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F53267-0.08ML

Properties

Application: WB, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: This FBXW7 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 177-208 amino acids from the N-terminal region of human FBXW7.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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