Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-720A-T 10 µl (10 µg) -

3 - 9 business days

A301-720A 100 µl (100 µg) -

3 - 9 business days

Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3... more
Product information "Anti-FBW7"
Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:29149593, PubMed:25775507). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1. Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). [The UniProt Consortium]
Keywords: Anti-hAgo, Anti-hCdc4, Anti-SEL-10, Anti-F-box protein FBX30, Anti-Archipelago homolog, Anti-F-box/WD repeat-containing protein 7, Anti-F-box and WD-40 domain-containing protein 7
Supplier: Bethyl Laboratories
Supplier-Nr: A301-720A


Application: IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Rat, X. Laevis, X. Tropicalis, Turkey, Dog, Rabbit, Swine, Panda, Rhesus Monkey, Gorilla, Chimpanzee, Duckbill Platypus, Tasmanian Devil, White-tufted-ear Marmoset, Crab-eating Macaque, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A301-720A maps to a region between residue 1 and 50 of human F-box and WD-40 domain protein 7 using the numbering given in entry NP_361014.1 (GeneID 55294).
Format: Antigen Affinity Purified

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