Protein function: Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). [The UniProt Consortium]
Human (Expected: Dog, Horse, Rabbit, Guinea Pig_10141, Pig, Panda, Orangutan, Gorilla, Chimpanzee, White-tufted-ear Marmoset, African Elephant, Chinese Hamster, Naked Mole Rat, Thirteen-lined Ground Squirrel, Northern White-cheeked Gibbon)
synthetic peptide. The epitope recognized by A303-367A-T maps to a region between residue 1173 and 1223 of human Family with Sequence Similarity 65, Member A using the numbering given in entry NP_001180451.1 (GeneID 79567).