Anti-FAIM1 (Fas Apoptotic Inhibitory Molecule 1, FAIM)

Anti-FAIM1 (Fas Apoptotic Inhibitory Molecule 1, FAIM)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
F0019-53J3.100 100 µl - -

1 - 19 business days

496.00€
 
FAIM (Fas apoptosis inhibitory molecule) was identified as a protein that was inducibly expressed... more
Product information "Anti-FAIM1 (Fas Apoptotic Inhibitory Molecule 1, FAIM)"
FAIM (Fas apoptosis inhibitory molecule) was identified as a protein that was inducibly expressed in B lymphocytes resistant to Fas-mediated apoptosis (1). Expression of FAIM inhibits receptor-mediated apoptosis in B cells as well as other cell types (1-3). FAIM is expressed in germinal center B cells, is positively regulated by IRF-4, and is also capable of inducing IRF-4 expression in a feed-forward mechanism (4). FAIM also regulates T cell receptor-mediated apoptosis by modulating Akt activation and Nur77 expression (2). Knockout mice for FAIM show an increased sensitivity to Fas-mediated apoptosis within B and T cells as well as hepatocytes (5). An alternatively spliced form of FAIM, termed FAIM-L, is found predominantly in the brain (6). In the nervous system, the originally identified FAIM does not appear to play a role in apoptosis, but rather can promote neurite outgrowth through the activation of Erk and NF-kB pathways (7). In contrast, FAIM-L does inhibit neuronal cell death triggered by death receptors (3). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-Fas apoptotic inhibitory molecule 1
Supplier: United States Biological
Supplier-Nr: F0019-53J3

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide corresponding to residues surrounding Gly145 of human FAIM.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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