Anti-FADD (Fas-Associated Death Domain Protein, MORT1)

Anti-FADD (Fas-Associated Death Domain Protein, MORT1)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
F0019-51F.100 100 µl - -

3 - 19 business days

456.00€
 
Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter... more
Product information "Anti-FADD (Fas-Associated Death Domain Protein, MORT1)"
Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1beta-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation. Applications: Suitable for use in ELISA, Western Blotting. Other applications not tested. Recommended Dilution: Western Blotting: 1:500-1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Hybridoma: Mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human FADD protein. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: F0019-51F

Properties

Application: ELISA, WB
Antibody Type: Monoclonal
Clone: 9A210
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Recombinant human FADD (1-208aa) purified from E. coli
Purity: Purified
Format: Purified

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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