Anti-Exportin-5

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-991A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-991A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-991A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Mediates the nuclear export of proteins bearing a double-stranded RNA binding... more
Product information "Anti-Exportin-5"
Protein function: Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner. [The UniProt Consortium]
Keywords: Anti-Exp5, Anti-XPO5, Anti-KIAA1291, Anti-Exportin-5, Anti-Ran-binding protein 21
Supplier: Bethyl Laboratories
Supplier-Nr: A303-991A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, Bovine, Dog, Horse, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Chinese Hamster, European Domestic Ferret, Little Brown Bat, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A303-991A-T maps to a region between residue 1154 to 1204 of human Exportin 5 using the numbering given in entry NP_065801.1 (GeneID 57510).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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