Protein function: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. [The UniProt Consortium]
Anti-EXOI, Anti-EXO1, Anti-hExoI, Anti-hExo1, EC=3.1.-.-, Anti-Exonuclease 1, Anti-Exonuclease I
Human (Expected: Orangutan, Gorilla, Chimpanzee, Northern White-cheeked Gibbon)
synthetic peptide. The epitope recognized by A302-640A-T maps to a region between residue 796 and 846 of human exonuclease 1 using the numbering given in entry NP_006018.3 (GeneID 9156).