Protein function: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. [The UniProt Consortium]
Anti-EWS, Anti-EWSR1, Anti-EWS oncogene, Anti-RNA-binding protein EWS, Anti-Ewing sarcoma breakpoint region 1 protein
synthetic peptide. The epitope recognized by IHC-00086 maps to a region between residue 100 and 150 of human Ewing sarcoma breakpoint region 1 using the numbering given in SwissProt entry Q01844 (GeneID 2130).