Anti-ERO1 (ERO1-Lalpha, Oxidoreductin-1-Lalpha, Endoplasmic Oxidoreductin-1-like Protein, ERO1-L)

Anti-ERO1 (ERO1-Lalpha, Oxidoreductin-1-Lalpha, Endoplasmic Oxidoreductin-1-like Protein, ERO1-L)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E3452-85.100 100 µl - -

3 - 19 business days

498.00€
 
Perhaps the most distinctive feature of protein folding in the ER is the abundance of disulfide... more
Product information "Anti-ERO1 (ERO1-Lalpha, Oxidoreductin-1-Lalpha, Endoplasmic Oxidoreductin-1-like Protein, ERO1-L)"
Perhaps the most distinctive feature of protein folding in the ER is the abundance of disulfide bonds that must form during maturation of proteins traveling along the secretory pathway. Formation of disulfide bonds is a redox reaction. Thus, to match the flux of disulfide bonds that exit from the ER by virtue of protein secretion, a flux of oxidizing equivalents into the ER is required. In eukaryotic cells, the essential protein relay supporting this flux, and hence disulfide bond formation, involves endoplasmic reticulum oxidoreductin 1 (Ero1) and protein disulfide isomerase (PDI). The temporal pattern of hypoxic ERO1-L alpha induction is very similar to that of genes triggered by the hypoxia inducible transcription factor (HIF-1) and is characteristically mimicked by cobalt and by deferoxamine, but is absent in cells with a defective aryl hydrocarbon receptor translocator (ARNT, HIF-1 alpha). We speculate from these findings that the expression of ERO1-L alpha is probably regulated via the HIF-pathway and thus belongs to the family of classic oxygen regulated genes. Positive Control: 293T, INS-1, and MIN6 cell lysates. , Applications: , Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: E3452-85

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide made the the N-terminal region of the human protein. [UniProt Q96HE7].
Purity: Purified by immunoaffinity chromatography.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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