Anti-erbB-2

Item number Size Datasheet Manual SDS Delivery time Quantity Price
200-901-BB7 100 µg - -

6 - 10 business days*

684.00€
 
Anti-erbB-2 Antibody is an IgY fraction antibody purified from monospecific chicken egg yolks by... more
Product information "Anti-erbB-2"
Anti-erbB-2 Antibody is an IgY fraction antibody purified from monospecific chicken egg yolks by a multi-step process which includes selective precipitation and salt fractionation followed by extensive dialysis against the buffer stated above. Cross reactivity with erbB-2 from other sources has not been determined. Protein function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. [The UniProt Consortium]
Keywords: Anti-HER2, Anti-CD340, Anti-ERBB2, Anti-MLN 19, Anti-p185erbB2, EC=2.7.10.1, Anti-Proto-oncogene Neu, Anti-Proto-oncogene c-ErbB-2, Anti-Metastatic lymph node gene 19 protein, Anti-Receptor tyrosine-protein kinase erbB-2, Anti-Tyrosine kinase-type cell su
Supplier: Rockland Immunochemicals
Supplier-Nr: 200-901-BB7

Properties

Application: ELISA, IHC, IFM, IP, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Chicken
Species reactivity: human, mouse, rat
Immunogen: 19 amino acid synthetic peptide near the C-terminus of human erbB-2.

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-erbB-2"
Write a review
or to review a product.
Viewed