Protein function: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR), internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. [The UniProt Consortium]
synthetic peptide. The epitope recognized by A301-733A-T maps to a region between residue 846 and 896 of human epidermal growth factor receptor pathway substrate 15 using the numbering given in entry NP_001972.1 (GeneID 2060).