Anti-EMI1 (Early Mitotic Inhibitor-1), clone EMI1/1176

Anti-EMI1 (Early Mitotic Inhibitor-1), clone EMI1/1176
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2527SAF-100UG 100 µg - -

3 - 10 business days*

752.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. EMI1 regulates mitosis by inhibiting the... more
Product information "Anti-EMI1 (Early Mitotic Inhibitor-1), clone EMI1/1176"
1 mg/ml in sterile PBS, BSA free, sodium azide free. EMI1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. Protein function: Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. [The UniProt Consortium]
Keywords: Anti-EMI1, Anti-FBXO5, Anti-F-box only protein 5, Anti-Early mitotic inhibitor 1, EMI1 Antibody (Early Mitotic Inhibitor-1)
Supplier: NSJ Bioreagents
Supplier-Nr: V2527SAF

Properties

Application: FC, IF, WB, IHC (paraffin)
Antibody Type: Monoclonal
Clone: EMI1/1176
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: A 203 amin acid recombinant fragment from the N-terminus of human EMI1 protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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