Anti-EMI-1, clone FBXP5

Anti-EMI-1, clone FBXP5
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V7090IHC-7ML 7 ml - -

3 - 10 business days*

752.00€
 
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. Early... more
Product information "Anti-EMI-1, clone FBXP5"
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. Protein function: Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. [The UniProt Consortium]
Keywords: Anti-EMI1, Anti-FBXO5, Anti-F-box only protein 5, Anti-Early mitotic inhibitor 1, EMI-1 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V7090IHC

Properties

Application: IHC
Antibody Type: Monoclonal
Clone: FBXP5
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: A human partial recombinant N-terminal protein fragment was used as the immunogen for the EMI-1 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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