Anti-eIF3K/EIF3S12

Anti-eIF3K/EIF3S12
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-763A-T 20 µl (2 blots) -

3 - 9 business days

125.00€
A301-763A-M 100 µl (10 blots) -

3 - 9 business days

299.00€
A301-763A 100 µl (20 µg) -

3 - 9 business days

443.00€
 
Protein function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex,... more
Product information "Anti-eIF3K/EIF3S12"
Protein function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF- 3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). [The UniProt Consortium]
Keywords: Anti-eIF3k, Anti-ARG134, Anti-PLAC-24, Anti-eIF-3 p25, Anti-eIF-3 p28, Anti-Muscle-specific gene M9 protein, Anti-Eukaryotic translation initiation factor 3 subunit K, Anti-Eukaryotic translation initiation factor 3 subunit 12
Supplier: Bethyl Laboratories
Supplier-Nr: A301-763A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Bovine)
Immunogen: synthetic peptide. The epitope recognized by A301-762A maps to a region between residue 168 and 218 of human eukaryotic translation initiation factor 3, subunit K (eukaryotic translation initiation factor 3, subunit 12) using the numbering given in entry NP_037366.1 (GeneID
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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