Anti-eIF3G

Anti-eIF3G
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-11-8056-25 25 µg -

2 - 11 business days

106.00€
 
Eukaryotic translation initiation factor 3, subunit G (eIF3G) represents a subunit of a... more
Product information "Anti-eIF3G"
Eukaryotic translation initiation factor 3, subunit G (eIF3G) represents a subunit of a eukaryotic translation initiation factor 3 (eIF3) complex. eIF3 is a large multisubunit protein complex that plays an essential role in the binding of the initiator methionyl-tRNA and mRNA to the 40S ribosomal subunit to form the 40S initiation complex.eIF3G is constitutively expressed in many tissues and is involved in ribosome recruitment. Protein function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF- 3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. [The UniProt Consortium]
Keywords: Anti-eIF3g, Anti-eIF3 p42, Anti-eIF3 p44, Anti-eIF-3-delta, Anti-eIF-3 RNA-binding subunit, Anti-Eukaryotic translation initiation factor 3 subunit 4, Anti-Eukaryotic translation initiation factor 3 subunit G, Polyclonal Antibody to eIF3G
Supplier: Abeomics
Supplier-Nr: 11-8056-25

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse)
Immunogen: A partial length recombinant eIF3G protein (amino acids 121-312) was used as the immunogen for this antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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