Anti-EHMT1

Anti-EHMT1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-642A-T 20 µl (2 blots) -

3 - 9 business days

125.00€
A301-642A-M 100 µl (10 blots) -

3 - 9 business days

299.00€
A301-642A 100 µl (20 µg) -

3 - 9 business days

443.00€
 
Protein function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of... more
Product information "Anti-EHMT1"
Protein function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non- histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. [The UniProt Consortium]
Keywords: Anti-GLP, Anti-GLP1, Anti-EHMT1, Anti-EUHMTASE1, EC=2.1.1.-, Anti-Eu-HMTase1, EC=2.1.1.43, Anti-H3-K9-HMTase 5, Anti-G9a-like protein 1, Anti-Lysine N-methyltransferase 1D, Anti-Histone H3-K9 methyltransferase 5
Supplier: Bethyl Laboratories
Supplier-Nr: A301-642A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Crab-eating Macaque)
Immunogen: synthetic peptide. The epitope recognized by A301-642A maps to a region between residue 25 and 75 of human euchromatic histone-lysine N-methyltransferase 1 using the numbering given in entry NP_079033.3 (GeneID 79813).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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