Anti-E-Cadherin / CDH1, clone SPM381

Anti-E-Cadherin / CDH1, clone SPM381
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3321-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V3321-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. Recognizes a protein... more
Product information "Anti-E-Cadherin / CDH1, clone SPM381"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. Recognizes a protein of 80-120kDa, identified as E-cadherin/CDH1. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as b-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma. Protein function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. [The UniProt Consortium]
Keywords: Anti-CDHE, Anti-CDH1, E-Cadherin Antibody / CDH1
Supplier: NSJ Bioreagents
Supplier-Nr: V3321-20UG

Properties

Application: FC, IF, WB, IHC (paraffin)
Antibody Type: Monoclonal
Clone: SPM381
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: A recombinant human protein was used as the immunogen for the E-Cadherin antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-E-Cadherin / CDH1, clone SPM381"
Write a review
or to review a product.
Viewed