Anti-E-Cadherin (CDH1) / CD324 (Intercellular Junction Marker) Recombinant Mouse Monoclonal Antibody

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-12-1170-100 100 µg -

3 - 11 business days*

850.00€
 
Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of... more
Product information "Anti-E-Cadherin (CDH1) / CD324 (Intercellular Junction Marker) Recombinant Mouse Monoclonal Antibody"
Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as -catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma. Protein function: Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. [The UniProt Consortium]
Keywords: Anti-CDHE, Anti-CDH1, Anti-E-Cadherin (CDH1) / CD324 (Intercellular Junction Marker) Recombinant Mouse Monoclonal Antibody (Clone:rCDH1/1525)
Supplier: Abeomics
Supplier-Nr: 12-1170

Properties

Application: IHC
Antibody Type: Monoclonal
Clone: rCDH1/1525
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant full-length human E-Cadherin protein
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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