Anti-DNA topoisomerase II, CT (TOP2A, TOP2, DNA topoisomerase 2-alpha isozyme) (Azide free) (APC)

Anti-DNA topoisomerase II, CT (TOP2A, TOP2, DNA topoisomerase 2-alpha isozyme) (Azide free) (APC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
034689-APC.200 200 µl - -

3 - 19 business days*

993.00€
 
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of... more
Product information "Anti-DNA topoisomerase II, CT (TOP2A, TOP2, DNA topoisomerase 2-alpha isozyme) (Azide free) (APC)"
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Applications: Suitable for use in Western Blot, FLISA, Recommended Dilution: FLISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Keywords: Anti-TOP2, Anti-TOP2A, EC=5.99.1.3, Anti-DNA topoisomerase 2-alpha, Anti-DNA topoisomerase II, alpha isozyme
Supplier: United States Biological
Supplier-Nr: 034689-APC

Properties

Application: FLISA, WB
Antibody Type: Polyclonal
Conjugate: APC
Host: Rabbit
Species reactivity: human
Immunogen: TOP2A/Topo antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1433-1461 amino acids from the C-terminal region of human TOP2A/Topo?.
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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