Anti-DNA Ligase IV

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Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-31212.20 20 µl - -

approx. 1-3 business days

63.00€
E-AB-31212.60 60 µl - -

7 - 17 business days

119.00€
E-AB-31212.120 120 µl - -

7 - 17 business days

211.00€
E-AB-31212.200 200 µl - -

7 - 17 business days

367.00€
 
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a... more
Product information "Anti-DNA Ligase IV"
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. Protein function: Efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA- dependent protein kinase complex DNA-PK to these DNA ends. [The UniProt Consortium]
Keywords: Anti-LIG4, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4, DNA Ligase IV Polyclonal Antibody
Supplier-Nr: E-AB-31212

Properties

Application: WB, IHC (paraffin), IF, ELISA
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human
Immunogen: Synthesized peptide derived from the Internal region of human DNA Ligase IV
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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