Anti-DKK3 (Dickkopf-related Protein 3, Dickkopf-3, Dkk-3, REIC, RIG, NQ258/PRO295)

Anti-DKK3 (Dickkopf-related Protein 3, Dickkopf-3, Dkk-3, REIC, RIG, NQ258/PRO295)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
030149.100 100 µg - -

3 - 19 business days*

505.00€
 
This gene encodes a protein that is a member of the dickkopf family. The secreted protein... more
Product information "Anti-DKK3 (Dickkopf-related Protein 3, Dickkopf-3, Dkk-3, REIC, RIG, NQ258/PRO295)"
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50-55aa in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12aa. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart. Applications: Western Blot: 1:500-1:2000 Immunohistochemistry: 1:200-1:1000, Flow Cytometry: 1:200-1:400, ELISA: 1:10000, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-REIC, Anti-DKK3, Anti-Dkk-3, Anti-hDkk-3, Anti-Dickkopf-3, Anti-Dickkopf-related protein 3
Supplier: United States Biological
Supplier-Nr: 030149

Properties

Application: ELISA, FC, IHC, WB
Antibody Type: Monoclonal
Clone: 13B227
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Purified recombinant fragment of human DKK3 (AA: 91-350 ) expressed in E. coli.

Database Information

UniProt ID : Q9UBP4 | Find alternatives
Gene ID GeneID 27122 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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