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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
D3790-01D.40 | 40 µg | - | - |
3 - 19 business days* |
419.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
DJ-1 belongs to the C56 peptidase family. It acts as a positive regulator of androgen... more
Product information "Anti-DJ-1 (PARK7, Parkinson Disease (Autosomal Recessive, Early Onset) 7, FLJ27376, Oncogene DJ1)"
DJ-1 belongs to the C56 peptidase family. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone and a sensor for oxidative stress. It apparently protects neurons against oxidative stress and cell death. Defects in PARK7 gene cause autosomal recessive early-onset Parkinson disease 7. Specifically, defects in PARK7 are characterized by PD onset before the age of 40, slow progression of the condition, and initial good response to levodopa. Parkinson's disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. However, cases of early-onset PD are sometimes found. PD generally arises as a sporadic condition but can be inherited as a simple Mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at an earlier age and are associated with atypical clinical features. PD is characterized by bradykinesia, resting tremors, muscular rigidity, and postural instability as well as by a significant clinical response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of protein aggregates) in surviving neurons at various areas of the brain. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 0.05-0.2ug/ml, Western Blot: 0.5-1ug/ml, Immunohistochemistry: 5-10ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | EC=3.4.-.-, Anti-Protein DJ-1, Anti-Parkinson disease protein 7 |
Supplier: | United States Biological |
Supplier-Nr: | D3790-01D |
Properties
Application: | ELISA, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Synthetic peptide within residues 50-100 of human DJ-1 protein. |
Purity: | Purified by Immunoaffinity chromatography. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K05687 | Matching products |
UniProt ID : | Q99497 | Matching products |
Gene ID | GeneID 11315 | Matching products |
Handling & Safety
Storage: | -20°C (-20°C Glycerol) |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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