Anti-DHX36

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-525A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A300-525A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Proposed to have a global role in regulating mRNA expression including... more

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Product information "Anti-DHX36"

Protein function: Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation, the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification. [The UniProt Consortium]

Keywords:	Anti-G4R1, Anti-DDX36, Anti-DHX36, EC=3.6.4.12, EC=3.6.4.13, Anti-G4-resolvase 1, Anti-MLE-like protein 1, Anti-DEAH box protein 36, Anti-ATP-dependent RNA helicase DHX36, Anti-RNA helicase associated with AU-rich element ARE
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-525A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: orangutan, rhesus monkey, gorilla, crab-eating macaque, thirteen-lined ground squirrel, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A300-525A-T maps to a region between residue 950 and the C-terminus (residue 1008) of human DEAH (Asp-Glu-Ala-His) Box Polypeptide 36 using the numbering given in entry NP_065916.1 (GeneID 170506).
Format:	Antigen Affinity Purified