Anti-DGCR8 (IHC)

Anti-DGCR8 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00688-T 10 µl (5+ slides) -

3 - 9 business days

125.00€
IHC-00688 100 µl (50+ slides) -

3 - 9 business days

456.00€
 
Protein function: Component of the microprocessor complex that acts as a RNA- and heme-binding... more
Product information "Anti-DGCR8 (IHC)"
Protein function: Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal. [The UniProt Consortium]
Keywords: Anti-DGCR8, Anti-LP4941, Anti-C22orf12, Anti-DiGeorge syndrome critical region 8, Anti-Microprocessor complex subunit DGCR8
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00688-T

Properties

Application: IHC
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Crab-eating Macaque, Northern White-cheeked Gibbon)
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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