Anti-DDR1

Anti-DDR1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
030141.100 100 µl - -

3 - 19 business days*

438.00€
 
DDR1: discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key... more
Product information "Anti-DDR1"
DDR1: discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. Applications: Western Bloting: 1:500-1:2000., ELISA: Suggested dilution 1:10000., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-CAK, Anti-HGK2, Anti-DDR1, Anti-TRK E, Anti-CD167a, Anti-MCK-10, EC=2.7.10.1, Anti-Tyrosine kinase DDR, Anti-Cell adhesion kinase, Anti-Protein-tyrosine kinase 3A, Anti-Tyrosine-protein kinase CAK, Anti-Mammary carcinoma kinase 10
Supplier: United States Biological
Supplier-Nr: 030141

Properties

Application: ELISA, WB
Antibody Type: Monoclonal
Clone: 13B219
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Purified recombinant fragment of DDR1 (aa602-681) expressed in E. coli.

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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