Anti-Cytokeratin 8 (C-Term) Rabbit

Anti-Cytokeratin 8 (C-Term) Rabbit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay32216-100 100 µl -

6 - 10 business days*

480.00€
 
Cytokeratin 8 is a type II epithelial intermediate filament protein. It is composed of a central... more
Product information "Anti-Cytokeratin 8 (C-Term) Rabbit"
Cytokeratin 8 is a type II epithelial intermediate filament protein. It is composed of a central rod containing four alpha-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. Cytokeratin 8 is expressed in single-layered epithelial cells and epithelial-derived tumor cells. It dimerizes with the type I epithelial intermediate filament protein cytokeratin 18 to form a network of filament bundles throughout the cytoplasm. The tail of cytokeratin 8 binds to plasminogen and mediates invasiveness of cancer cells in vitro. A null mutation in KRT8, the gene encoding cytokeratin 8, is embryonic lethal in C57BL/6 x 129Sv, but not FVB/N, mice, which develop colorectal hyperplasia. Substitution mutations in KRT8, corresponding to residues in the head domain of the protein, disrupt filament reorganization following oxidative and non-oxidative stress in vitro and are associated with cryptogenic liver disease. Intratumoral levels of cytokeratin 8 and -18 are correlated with poor prognosis in patients with squamous cell carcinomas of the oral cavity. Cayman's Cytokeratin 8 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: CK-8, Keratin, Type II Cytoskeletal 8, Keratin-8, KRT8. Immunogen: Peptide from the C-terminal region of human cytokeratin 8. Clone Designation: RM266. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC and WB. Cross Reactivity: (+) Cytokeratin 8.
Keywords: CK-8, Keratin, Type II Cytoskeletal 8, Keratin-8, KRT8
Supplier: Cayman Chemical
Supplier-Nr: 32216

Properties

Application: IHC, WB
Antibody Type: Monoclonal
Clone: RM266
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Peptide from the C-terminal region of human cytokeratin 8
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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