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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32216-100 | 100 µl | - |
6 - 10 business days* |
480.00€
|
Cytokeratin 8 is a type II epithelial intermediate filament protein. It is composed of a central... more
Product information "Anti-Cytokeratin 8 (C-Term) Rabbit"
Cytokeratin 8 is a type II epithelial intermediate filament protein. It is composed of a central rod containing four alpha-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. Cytokeratin 8 is expressed in single-layered epithelial cells and epithelial-derived tumor cells. It dimerizes with the type I epithelial intermediate filament protein cytokeratin 18 to form a network of filament bundles throughout the cytoplasm. The tail of cytokeratin 8 binds to plasminogen and mediates invasiveness of cancer cells in vitro. A null mutation in KRT8, the gene encoding cytokeratin 8, is embryonic lethal in C57BL/6 x 129Sv, but not FVB/N, mice, which develop colorectal hyperplasia. Substitution mutations in KRT8, corresponding to residues in the head domain of the protein, disrupt filament reorganization following oxidative and non-oxidative stress in vitro and are associated with cryptogenic liver disease. Intratumoral levels of cytokeratin 8 and -18 are correlated with poor prognosis in patients with squamous cell carcinomas of the oral cavity. Cayman's Cytokeratin 8 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: CK-8, Keratin, Type II Cytoskeletal 8, Keratin-8, KRT8. Immunogen: Peptide from the C-terminal region of human cytokeratin 8. Clone Designation: RM266. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC and WB. Cross Reactivity: (+) Cytokeratin 8.
Keywords: | CK-8, Keratin, Type II Cytoskeletal 8, Keratin-8, KRT8 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32216 |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | RM266 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Peptide from the C-terminal region of human cytokeratin 8 |
Format: | Purified |
Database Information
KEGG ID : | K07605 | Matching products |
UniProt ID : | P05787 | Matching products |
Gene ID | GeneID 3856 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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