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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32307-100 | 100 µl | - |
6 - 10 business days* |
480.00€
|
Cytokeratin 5 (CK5) and CK6 are type II intermediate filament proteins. They are each composed of... more
Product information "Anti-Cytokeratin 5/Cytokeratin 6 (C-Term) Rabbit"
Cytokeratin 5 (CK5) and CK6 are type II intermediate filament proteins. They are each composed of a central rod containing four alpha-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. CK5 is expressed in basal keratinocytes in the epidermis and is an integral component of the epithelial cell cytoskeleton. It dimerizes with the type I epithelial intermediate filament protein CK14 via heptad repeats in the central rod domain to form a network of filament bundles throughout the cytoplasm. CK6 expression is restricted to ectoderm-derived epithelial appendages, such as hair follicles, nails, and teeth, but is induced at sites of wound injury and persists until barrier function is restored and the wound is closed. CK5 and CK6 are associated with poor prognosis in patients with high-grade serous ovarian carcinoma or triple-negative breast cancers. Cayman's Cytokeratin 5/Cytokeratin 6 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: CK5/CK6, Keratin, Type II Cytoskeletal 5/6, Keratin 5/Keratin 6, KRT5/KRT6. Immunogen: Peptide from the C-terminal region of human cytokeratin 5. Clone Designation: RM341. Formulation: (Request formulation change), 100 µl of Protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) Cytokeratin 5, (+) Cytokeratin 6.
Keywords: | CK5/CK6, Keratin 5/Keratin 6, Keratin, Type II Cytoskeletal 5/6, KRT5/KRT6 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32307 |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | RM341 |
Conjugate: | No |
Host: | Rabbit |
Immunogen: | Peptide from the C-terminal region of human cytokeratin 5 |
Format: | Purified |
Database Information
KEGG ID : | K07605 | Matching products |
UniProt ID : | P13647 | Matching products |
Gene ID | GeneID 3852 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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