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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32229-100 | 100 µl | - |
6 - 10 business days* |
480.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Cytokeratin 18 (CK18) is an intermediate filament protein and a member of the cytokeratin protein... more
Product information "Anti-Cytokeratin 18 Rabbit Monoclonal Antibody (Clone RM279)"
Cytokeratin 18 (CK18) is an intermediate filament protein and a member of the cytokeratin protein family. It is a type I acidic cytokeratin expressed in epithelial tissues, including those found in liver, lung, kidney, pancreas, and the gastrointestinal tract, and is localized in the cytoplasm and perinuclear region. CK18 is co-expressed with the type II neutral-basic cytokeratin CK8, with which it forms intermediate filaments essential to cytoplasmic structure. During apoptosis, CK18 is cleaved by caspases and released from the cell, and is commonly used as a marker of epithelial cell death. Plasma levels of CK18 positively correlate with the magnitude of hepatocyte apoptosis in patients with non-alcoholic fatty liver disease (NAFLD) and are independently predictive of non-alcoholic steatohepatitis (NASH). Serum levels of CK18 are elevated in patients with cardiometabolic disorders, including diabetes and hypertension, in an NAFLD-independent manner. CK18 tumor expression positively correlates with poorly differentiated oral squamous cell carcinoma (OSCC) tumors and poor prognosis. Cayman's Cytokeratin 18 Rabbit Monoclonal Antibody (Clone RM279) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: CK-18, Keratin-18, Keratin, Type II Cytoskeletal 18, KRT18. Immunogen: Peptide from the N-terminal region of human cytokeratin 18. Clone Designation: RM279. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) Cytokeratin 18.
Keywords: | CK-18, Keratin, Type II Cytoskeletal 18, Keratin-18, KRT18 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32229 |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | RM279 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Peptide from the N-terminal region of human cytokeratin 18 |
Format: | Purified |
Database Information
KEGG ID : | K07604 | Matching products |
UniProt ID : | P05783 | Matching products |
Gene ID | GeneID 3875 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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