Anti-Cytokeratin 18, clone RM279

Anti-Cytokeratin 18, clone RM279
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay32229-100 100 µl - -

3 - 10 business days*

Cytokeratin 18 (CK18) is an intermediate filament protein and a member of the cytokeratin protein... more
Product information "Anti-Cytokeratin 18, clone RM279"
Cytokeratin 18 (CK18) is an intermediate filament protein and a member of the cytokeratin protein family. It is a type I acidic cytokeratin expressed in epithelial tissues, including those found in liver, lung, kidney, pancreas, and the gastrointestinal tract, and is localized in the cytoplasm and perinuclear region. CK18 is co-expressed with the type II neutral-basic cytokeratin CK8, with which it forms intermediate filaments essential to cytoplasmic structure. During apoptosis, CK18 is cleaved by caspases and released from the cell, and is commonly used as a marker of epithelial cell death. Plasma levels of CK18 positively correlate with the magnitude of hepatocyte apoptosis in patients with non-alcoholic fatty liver disease (NAFLD) and are independently predictive of non-alcoholic steatohepatitis (NASH). Serum levels of CK18 are elevated in patients with cardiometabolic disorders, including diabetes and hypertension, in an NAFLD-independent manner. CK18 tumor expression positively correlates with poorly differentiated oral squamous cell carcinoma (OSCC) tumors and poor prognosis. Cayman's Cytokeratin 18 Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Keywords: Anti-K18, Anti-PIG46, Anti-CK-18, Anti-CYK18, Anti-KRT18, Anti-Keratin-18, Anti-Cytokeratin-18, Anti-Keratin, type I cytoskeletal 18, Anti-Cell proliferation-inducing gene 46 protein
Supplier: Cayman Chemical
Supplier-Nr: 32229-100


Application: IHC, WB
Antibody Type: Monoclonal
Clone: RM279
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Peptide from the N-terminal region of human cytokeratin 18
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
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