Anti-Cytokeratin 14 / CK14 / KRT14, clone SPM263

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V9058IHC-7ML 7 ml - -

3 - 10 business days*

752.00€
 
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-Cytokeratin 14 / CK14 / KRT14, clone SPM263"
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*. Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors. Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast. Protein function: The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. [The UniProt Consortium]
Keywords: Anti-K14, Anti-CK-14, Anti-KRT14, Anti-Keratin-14, Anti-Cytokeratin-14, Anti-Keratin, type I cytoskeletal 14, Cytokeratin 14 Antibody / CK14 / KRT14
Supplier: NSJ Bioreagents
Supplier-Nr: V9058IHC

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: SPM263
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: A 15 amino acid peptide from the C-terminus of human keratin 14
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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