Anti-Cytokeratin 14 (C-Term), clone RM328

Cytokeratin 14 (CK14) is a type I acidic epithelial intermediate filament protein. It is composed of a central rod containing four alpha-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. CK14 is expressed in stratified squamous epithelial cells, keratinocytes, and myoepithelial cells in the basal layer of the epidermis and is an integral component of the epithelial cell cytoskeleton. It dimerizes with the type II basic epithelial intermediate filament protein CK5 via heptad repeats in the central rod domain to form a network of filament bundles throughout the cytoplasm. Increased tumor levels of CK14 have been found in patients with squamous cell carcinomas of the bladder, lung, or cervix. Mutations in the gene encoding CK14 have been found in patients with epidermolysis bullosa simplex (EBS), a disorder characterized by skin blistering. Cayman's Cytokeratin 14 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.