Anti-CysLT2 Receptor (N-Term)

Cysteinyl leukotriene receptor 2 (CysLT2) is a G protein-coupled receptor that mediates the actions of leukotriene C4 (LTC4), LTD4, and, to a lesser extent, LTE4. It is expressed primarily in the heart, placenta, spleen, lymph nodes, and peripheral blood leukocytes. Signaling induced by LTC4 through the CysLT2 receptor induces the production of chemokines via NF-kappaB and AP-1 activation in endothelial cells, indicating a role in inflammation. A CysLT2 receptor containing a leucine-to-glutamine substitution at position 129 (L129Q) has been found in human uveal melanoma cells and is associated with tumorigenesis in vivo. SNPs in CYSLTR2 are associated with aspirin intolerance in patients with asthma. Cayman's CysLT2 Receptor (N-Term) Polyclonal Antibody can be used for ELISA, flow cytometry (FC), and Western blot (WB) applications.Synonyms: Cysteinyl-Leukotriene Receptor 2, CysLTR2. Immunogen: Peptide corresponding to the N-terminal region of human CysLT2. Formulation: (Request formulation change), Peptide affinity-purified antibody. Storage Buffer: TBS, pH 7.4, when reconstituted in 500 µl double distilled water. Host: Rabbit. Applications: ELISA, FC, and WB. Cross Reactivity: (+) CysLT2, (-) CysLT1. UniProt Accession #: Q9NS75. Origin: Animal/Rabbit.