Anti-Cul2

Anti-Cul2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-476A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-476A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-476A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box... more
Product information "Anti-Cul2"
Protein function: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). [The UniProt Consortium]
Keywords: Anti-CUL2, Anti-CUL-2, Anti-Cullin-2
Supplier: Bethyl Laboratories
Supplier-Nr: A302-476A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Mouse, Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A302-476A-T maps to a region between residue 695 and 745 of human cullin 2 using the numbering given in entry NP_003582.2 (GeneID 8453).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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