Anti-CSK

Anti-CSK
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R31527 100 µg - -

3 - 10 business days*

549.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CSK is a non-receptor protein tyrosine... more
Product information "Anti-CSK"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CSK is a non-receptor protein tyrosine kinase protein that in humans is encoded by the CSK gene. It is mapped to 15q24.1. CSK suppresses activity of the Src family of protein kinases by phosphorylation of family members at a conserved C-terminal site in Src. CSKs control of the Src family activity is widely thought to be central to regulation of the immune response. It can downregulate tyrosine kinase activity of the Src oncoprotein through tyrosine phosphorylation of the carboxy terminus. Since cell transformation by Src oncoproteins is caused by various mechanisms that interfere with this phosphorylation, the gene might function as an antioncogene. Protein function: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. [The UniProt Consortium]
Keywords: Anti-CSK, Anti-C-Src kinase, Anti-Protein-tyrosine kinase CYL, Anti-Tyrosine-protein kinase CSK, CSK Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: R31527

Properties

Application: WB, IHC (paraffin)
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Human partial recombinant protein (AA 2-204) was used as the immunogen for this CSK antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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