Anti-CRTC1

Anti-CRTC1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
030116.100 100 µl - -

3 - 19 business days*

477.00€
 
MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) functions as a transcriptional... more
Product information "Anti-CRTC1"
MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11,19) (q21,p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein. Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. Applications: Western Bloting: 1:500-1:2000., Immunofluorescence: 1:200-1:1000., Flow cytometry: 1:200-1:400., ELISA: Suggested dilution 1:10000., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-CRTC1, Anti-TORC-1, Anti-KIAA0616, Anti-Transducer of CREB protein 1, Anti-CREB-regulated transcription coactivator 1, Anti-Mucoepidermoid carcinoma translocated protein 1, Anti-Transducer of regulated cAMP response element-binding protein 1
Supplier: United States Biological
Supplier-Nr: 030116

Properties

Application: ELISA, FC, WB
Antibody Type: Monoclonal
Clone: 13B194
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Purified recombinant fragment of human CRTC1 expressed in E. coli.

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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