Protein function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). [The UniProt Consortium]
Anti-PBP, Anti-MED1, Anti-ARC205, Anti-TRIP-2, Anti-Trap220, Anti-PPAR-binding protein, Anti-TR-interacting protein 2, Anti-Mediator complex subunit 1, Anti-p53 regulatory protein RB18A, Anti-Thyroid receptor-interacting protein 2
Human, Mouse (Expected: Orangutan)
synthetic peptide. The epitope recognized by A300-793A-T maps to a region between residue 1525 and the C-terminus (residue 1581) of human Cofactor Required for Sp1 Transcriptional Activation 1using the numbering given in entry NP_004765.2 (GeneID 5469).