Anti-CPSF4, ID (CPSF4, CPSF30, NAR, NEB1, Cleavage and polyadenylation specificity factor subunit 4,

Anti-CPSF4, ID (CPSF4, CPSF30, NAR, NEB1, Cleavage and polyadenylation specificity factor subunit 4,
Item number Size Datasheet Manual SDS Delivery time Quantity Price
034180-HRP.200 200 µl - -

3 - 19 business days*

993.00€
 
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1... more
Product information "Anti-CPSF4, ID (CPSF4, CPSF30, NAR, NEB1, Cleavage and polyadenylation specificity factor subunit 4,"
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Applications: Suitable for use in Western Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. , , Note: Applications are based on unconjugated antibody.
Keywords: Anti-CPSF4, Anti-Neb-1, Anti-CPSF30, Anti-No arches homolog, Anti-CPSF 30 kDa subunit, Anti-NS1 effector domain-binding protein 1, Anti-Cleavage and polyadenylation specificity factor subunit 4
Supplier: United States Biological
Supplier-Nr: 034180-HRP

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: HRP
Host: Rabbit
Species reactivity: human
Immunogen: CPSF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102~132 amino acids from the Central region of human CPSF4.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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