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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V8038-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V8038-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Prostaglandins are a diverse group... more
Product information "Anti-COX2 / PTGS2, clone COX2/1941"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed. Protein function: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, that regulates phagocytic microglia. [The UniProt Consortium]
Keywords: | Anti-COX2, Anti-COX-2, Anti-PTGS2, Anti-PHS II, Anti-PGHS-2, Anti-PGH synthase 2, Anti-Cyclooxygenase-2, Anti-Prostaglandin H2 synthase 2, Anti-Prostaglandin G/H synthase 2, Anti-Prostaglandin-endoperoxide synthase 2, COX2 Antibody / PTGS2 |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V8038 |
Properties
Application: | ELISA, WB |
Antibody Type: | Monoclonal |
Clone: | COX2/1941 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A recombinant human partial protein (amino acids 442-572) |
Format: | Purified |
Database Information
KEGG ID : | K11987 | Matching products |
UniProt ID : | P35354 | Matching products |
Gene ID | GeneID 5743 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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