Anti-COX-2 (Clone CX229)

Anti-COX-2 (Clone CX229)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay160112-1 1 each -

6 - 10 business days*

422.00€
 
Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase... more
Product information "Anti-COX-2 (Clone CX229)"
Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins. The COX component converts arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2, Cay-17010), and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH2 (Cay-17020). COX2 expression is induced by a variety of stimuli, including phorbol esters, LPS, and cytokines and is responsible for the biosynthesis of PGs under acute inflammatory conditions. Thus, COX-2 has been the focus of attention for nonsteroidal anti-inflammatory drug (NSAID) development. Cayman's COX-2 (human) Monoclonal Antibody (Clone CX229) can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes a unique C-terminal region of COX-2 that is not present in COX-1, specifically detecting COX-2 ~70 kDa from human and ovine samples.Synonyms: Cyclooxygenase 2, PGHS-2, Prostaglandin H Synthase 2. Immunogen: Synthetic peptide from the C-terminal region of human protein COX-2. Clone Designation: CX229. Formulation: (Request formulation change), 50 µg of protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: IHC, WB. Cross Reactivity: (-) COX-1.
Keywords: Cyclooxygenase 2, PGHS-2, Prostaglandin H Synthase 2
Supplier: Cayman Chemical
Supplier-Nr: 160112

Properties

Application: IHC, WB
Antibody Type: Monoclonal
Clone: CX229
Conjugate: No
Host: Mouse
Species reactivity: human, ovine, monkey (Expected: bovine, canine)
Immunogen: Synthetic peptide from the C-terminal region of human protein COX-2
Format: Purified

Database Information

KEGG ID : K11987 | Matching products
UniProt ID : P35354 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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