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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ARG57561.100 | 100 µl | - | - |
6 - 14 business days* |
707.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Component of the COP9 signalosome complex (CSN), a complex involved in various... more
Product information "Anti-COPS6"
Protein function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor- responsive activity. Stabilizes COP1 through reducing COP1 auto- ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. [The UniProt Consortium]
| Keywords: | Anti-CSN6, Anti-SGN6, Anti-hVIP, Anti-COPS6, Anti-MOV34 homolog, Anti-Signalosome subunit 6, Anti-Vpr-interacting protein, Anti-COP9 signalosome complex subunit 6, Anti-JAB1-containing signalosome subunit 6 |
| Supplier: | Arigo Biolaboratories |
| Supplier-Nr: | ARG57561 |
Properties
| Application: | WB |
| Antibody Type: | Polyclonal |
| Conjugate: | No |
| Host: | Rabbit |
| Species reactivity: | mouse, rat (Expected: human) |
| Immunogen: | Recombinant protein of Human COPS6 |
| MW: | 36 kD |
| Format: | Affinity Purified |
Database Information
| KEGG ID : | K12179 | Matching products |
| UniProt ID : | Q7L5N1 | Matching products |
| Gene ID : | GeneID 10980 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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