Anti-COPS5, NT (COP9 Signalosome Complex Subunit 5, SGN5, Signalosome Subunit 5, Jun Activation Doma

Anti-COPS5, NT (COP9 Signalosome Complex Subunit 5, SGN5, Signalosome Subunit 5, Jun Activation Doma
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C7900-58J.100 100 µl - -

4 - 22 business days

496.00€
 
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various... more
Product information "Anti-COPS5, NT (COP9 Signalosome Complex Subunit 5, SGN5, Signalosome Subunit 5, Jun Activation Doma"
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. [The UniProt Consortium]
Keywords: EC=3.4.-.-, Anti-Signalosome subunit 5, Anti-COP9 signalosome complex subunit 5, Anti-Jun activation domain-binding protein 1
Supplier: United States Biological
Supplier-Nr: C7900-58J

Properties

Application: IF, IP, WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Bovine, Dog, Horse, Human, Monkey, Mouse, Swine, Rat, Xenopusnopus, Zebrafish
Immunogen: Synthetic peptide corresponding to residues near the amino-terminus of human COPS5.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-COPS5, NT (COP9 Signalosome Complex Subunit 5, SGN5, Signalosome Subunit 5, Jun Activation Doma"
Write a review
or to review a product.
Viewed