Anti-CNGA3 (Cyclic Nucleotide-gated Cation Channel alpha 3, CNGa2, CCNC1)

Anti-CNGA3 (Cyclic Nucleotide-gated Cation Channel alpha 3, CNGa2, CCNC1)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C6005-10.50 50 µl - -

3 - 19 business days*

612.00€
 
Cyclic nucleotides are important second messengers in many cellular functions such as visual... more
Product information "Anti-CNGA3 (Cyclic Nucleotide-gated Cation Channel alpha 3, CNGa2, CCNC1)"
Cyclic nucleotides are important second messengers in many cellular functions such as visual transduction, and relaxation of smooth muscle cells. Cyclic nucleotides exert their cellular functions through three major classes of cellular receptors, one of them is the cyclic nucleotide-gated (CNG) channels. 1 The CNG channels are non-selective cation channels facilitating the influx of Na +and Ca 2+ ions, following activation by intracellular cyclic nucleotides. 2In vertebrates, six members of the CNG channel family were identified and grouped according to sequence homology into two subtypes, CNGA and CNGB. The native CNG channels are composed of alpha and beta subunits in a tetrameric configuration. To date, four types of the alpha subunits (CNGA1-4) and two beta subunits (CNGB1, CNGB3) have been characterized. 3-4 Each subunit contains 6 TM domains and intracellular cAMP or cGMP binding domains but, are also modulated by other factors including phosphorylation and calmodulin. 5In a heterologous expression system, only the alpha subunits are capable of forming functional homomeric channels. CNG ion channels are essential in visual and olfactory signal transduction. The CNGA3 channel is primarily expressed in cone photoreceptors where it participates in light transduction (daylight and color vision). CNG channels expression was also found in the hippocampus, cortex, Purkinje cells and other neural derived tissues. CNGA3 was also detected in kidney, heart, brain and sperm, where it was thought to have an important role in the control of sperm motility and fertility. However, CNGA3-deficient mice were shown to be as fertile and produce at normal rate as wild types. 6, Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:200 using ECL on rat brain membrane lysate, Immunohistochemistry: on frozen rat brain sections. , Optimal dilutions to be determined by the researcher. Control antigen included , Storage and Stability:, May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-Cyclic nucleotide-gated channel
Supplier: United States Biological
Supplier-Nr: C6005-10

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Rat
Immunogen: Peptide (C)GHGFSPDRENSEDASKAD, corresponding to amino acid residues 594-611 of rat CNGA3 (accession number Q9QWN7).
Purity: Purified
Format: Purified

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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