Anti-Clusterin / ApoJ, C-terminal

Anti-Clusterin / ApoJ, C-terminal
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG64745.100 100 µg - -

6 - 14 business days*

784.00€
 
Protein function: Functions as extracellular chaperone that prevents aggregation of nonnative... more
Product information "Anti-Clusterin / ApoJ, C-terminal"
Protein function: Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promotes apoptosis when in the nucleus. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. [The UniProt Consortium]
Keywords: Anti-Clu, Anti-Apoj
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG64745

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Species reactivity: rat (Expected: mouse)
Immunogen: C-EKALQEYRRKSRAE
Format: Ammonium Sulfate Precipitated

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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