Anti-CLIM1/PDLIM1

PDLIM1 (PDZ and LIM Domain 1) belongs to the enigma protein family. It contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxy terminal. LIM domains are cysteine-rich double zinc fingers that are involved in protein-protein interactions. PDLIM1 has transcription coactivatior activity and it may play a role as an adapter to bring other LIM-interacting proteins to the cytoskeleton. This gene is found to be highly expressed in the heart and skeletal muscle and moderately expressed in the spleen. PDLIM1 consists of 329 amino acids and is associated with hyperacusis and supravalvular aortic stenosis diseases. Protein function: Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts. [The UniProt Consortium]