Anti-Citrullinated LL-37 (Clone 6A8)

Anti-Citrullinated LL-37 (Clone 6A8)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay26739-300 300 µg -

6 - 10 business days*

488.00€
 
LL-37 is a cationic alpha-helical peptide expressed in human bone marrow, testis, granulocytes,... more
Product information "Anti-Citrullinated LL-37 (Clone 6A8)"
LL-37 is a cationic alpha-helical peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and a variety of immune cells. It has antimicrobial and antiviral activity, and protein levels of LL-37 are increased in epithelial cells, macrophages, and neutrophils following bacterial infection in vitro. LL-37 can be citrullinated by protein arginine deiminase 2 (PAD2) and PAD4, a modification that reduces its antibacterial and antiviral activities. Citrullinated, unlike native, LL-37 does not prevent mortality in a mouse model of D-galactosamine-sensitized endotoxic shock. Citrullinated LL-37 has been found in neutrophil extracellular traps (NETs), as well as the serum of patients with rheumatoid arthritis (RA) and individuals without RA. Cayman's Citrullinated LL-37 Monoclonal Antibody (Clone 6A8) can be used for ELISA and Western blot (WB) applications. The antibody recognizes citrullinated LL-37 at approximately 9 kDa from human samples.Synonyms: Antibacterial Peptide LL-37, Antibacterial Protein LL-37. Immunogen: Citrullinated human LL-37 peptide. Clone Designation: 6A8. MW: ~9 kDa. Formulation: (Request formulation change), 300 µg of protein G-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: ELISA, WB. Cross Reactivity: (+) Citrullinated LL-37, (-) Native LL-37. UniProt Accession #: P49913.
Keywords: Anti-HSD26, Anti-CAP-18, Anti-hCAP-18, Anti-FALL-39 peptide antibiotic, Anti-Antibacterial peptide LL-37, Anti-Antibacterial peptide FALL-39, Anti-Cathelicidin antimicrobial peptide, Anti-18 kDa cationic antimicrobial protein
Supplier: Cayman Chemical
Supplier-Nr: 26739

Properties

Application: ELISA, WB
Antibody Type: Monoclonal
Clone: 6A8
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Citrullinated human LL-37 peptide
MW: 9 kD
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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