Anti-CDX-2 Monoclonal Antibody (Clone:IHC402)

Anti-CDX-2 Monoclonal Antibody (Clone:IHC402)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-44-1018-0.1 100 µl -

3 - 11 business days*

501.00€
 
CDX-2 is a caudal-related homeobox transcription factor that is expressed by intestinal... more
Product information "Anti-CDX-2 Monoclonal Antibody (Clone:IHC402)"
CDX-2 is a caudal-related homeobox transcription factor that is expressed by intestinal epithelial cells. CDX-2 is a useful marker for gastrointestinal carcinoma, and for determining the origin of gastrointestinal metastatic adenocarcinoma and carcinoids. Anti-CDX-2 is used for differentiating lung and metastatic colorectal adenocarcinoma, however mucinous ovarian carcinoma also react positively with Anti-CDX-2, thereby limiting the ability to differentiate from metastatic colorectal adenocarcinoma. Protein function: Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium. Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription. Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription. Binds to and activates transcription of LPH. Activates transcription of CLDN2 and intestinal mucin MUC2. Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). [The UniProt Consortium]
Keywords: Anti-CDX3, Anti-CDX2, Anti-CDX-3, Anti-Homeobox protein CDX-2, Anti-Caudal-type homeobox protein 2, Anti-CDX-2 Monoclonal Antibody (Clone:IHC402)
Supplier: Abeomics
Supplier-Nr: 44-1018-0.1

Properties

Application: IHC
Antibody Type: Monoclonal
Clone: IHC402
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant Human CDX-2
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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