Anti-CD79a Monoclonal Antibody (Clone:HM57)

Anti-CD79a Monoclonal Antibody (Clone:HM57)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-30-1368-0.1 100 µg -

3 - 11 business days*

594.00€
 
CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are... more
Product information "Anti-CD79a Monoclonal Antibody (Clone:HM57)"
CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. Protein function: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells. [The UniProt Consortium]
Keywords: Anti-IGA, Anti-CD79A, Anti-CD79a, Anti-Ig-alpha, Anti-MB-1 membrane glycoprotein, Anti-Surface IgM-associated protein, Anti-Membrane-bound immunoglobulin-associated protein, Anti-B-cell antigen receptor complex-associated protein alpha chain, Anti-CD79a M
Supplier: Abeomics
Supplier-Nr: 30-1368

Properties

Application: FC, IHC, IHC (frozen)
Antibody Type: Monoclonal
Clone: HM57
Conjugate: No
Host: Mouse
Species reactivity: human, pig, mouse, rat, bovine, equine, guinea pig, opossum, rabbit, chicken
Immunogen: Synthetic peptide corresponding to amino acids 202-216 of human CD79a
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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